Author Archives: adderall-expert

Adderall Generic vs Brand – Which is Best and Why

Adderall Generic vs Brand – Which is Best and Why?

Paying full price for Adderall is an experience no one wants to go through.  In 2002 the first generic was introduced for Adderall IR (Instant Release) by Barr Laboratories Inc (1).  Since then a number of new generics have popped up on the market.  I’m going to present you with the facts about generics and provide a list of the companies approved to manufacture generic Adderall.  Without further ado let’s compare Adderall generic vs brand!

It is very important to keep track of which generic works best for you as the absorption between the generic and the name brand can fluctuate as much as 10% and still be considered bioequivalent (in the United States per the FDA) (2).  

Studies have been done comparing the absorption of generics vs name brand drugs and have identified on average a 4.35% fluctuation in the absorption between them (3).

Adderall XR (Extended Release) Generic Brands

Shire, TEVA, and BARR generics all use the original formula.  You are taking a risk with the others in terms of “being just like the original”.

Manufacturer Approval Date
*SHIRE DEVELOPMENT INC Oct 11, 2001
ACTAVIS ELIZABETH LLC Jun 22, 2012
IMPAX LABORATORIES INC Feb 16, 2016
*TEVA PHARMACEUTICALS USA INC Apr 29, 2013
*BARR LABORATORIES INC Feb 12, 2013

* Shire is permitted to sell the original formula.

Adderall IR (Instant Release) Generic Brands

There are currently eleven manufacturer’s approved to sell generic instant release Adderall.  Only TEVA uses the original formula.

Manufacturer Approval Date
*TEVA (BARR LABORATORIES INC) Feb 11, 2002
SANDOZ INC Jun 14, 2002
EPIC PHARMA LLC Jun 19, 2002
SUN PHARMACEUTICAL INDUSTRIES INC Sep 9, 2003
SPECGX LLC Oct 7, 2003
AUROLIFE PHARMA LLC Nov 27, 2013
MYLAN PHARMACEUTICALS INC Nov 10, 2015
ACTAVIS ELIZABETH LLC Feb 5, 2016
ALVOGEN MALTA OPERATIONS LTD Jul 28, 2017
NESHER PHARMACEUTICALS USA LLC Oct 31, 2017
SUNRISE PHARMACEUTICAL INC Dec 28, 2017

* Only TEVA uses the original formula

Adderall Instant Release Best Generic – TEVA (aka BARR Laboratories)

Teva is by far the best because they use the original formula.  The first picture below shows a 20 mg tablet and the second a 30 mg tablet (4).

Wondering why the label author is listed as “Barr Laboratories Inc.” and I said this is Teva?  That’s because Teva acquired Barr Laboratories Inc. in 2008 (5)

Adderall Generic vs Brand - Which is Best and Why

References:

  1. “National Drug Code Amphetamine Search Results”National Drug Code Directory. United States Food and Drug Administration. Archived from the original on 16 December 2013. Retrieved 16 December 2013.
  2. Center for Drug Evaluation and Research (2003). “Guidance for Industry: Bioavailability and Bioequivalence Studies for Orally Administered Drug Products — General Considerations” (PDF). United States Food and Drug Administration.
  3. Comparing generic and innovator drugs: a review of 12 years of bioequivalence data from the United States Food and Drug Administration 2009 Oct;43(10):1583-97. doi: 10.1345/aph.1M141. Epub 2009 Sep 23.
  4. Identify or Search for a Pill. National Laboratory of Medicine.
  5. “Teva Completes Acquisition of Barr”. Drugs.com. Retrieved 31 October 2011.

Adderall Last Longer

How can you make your adderall last longer?  Quick tips to make your Adderall last longer.  This post will explore how to make the effects of adderall last longer.

adderall-last-longer

FAQ

Does Alka-Seltzer make Adderall Last Longer?

Yes

Alkalinizing Agents: Adderall absorbs better in less acidic gastrointestinal conditions. You can decrease the acidity of your GI tract by taking one or two tums or half a teaspoon of baking soda (mixed with water) about an hour before consuming the amphetamine. Be careful not to take too much baking soda, as its chemical reaction with stomach acid can cause nausea and vomiting 1-2,7.

Will Antacids and Proton Pump Inhibitors make my Adderall last longer?

Antacids1-2 and proton pump inhibitors3 increase the absorption of amphetamines, but not the duration!

Will food effect my Adderall ?

Yes, try not to eat before taking your adderall or immediately afterward.

A study compared the effect of a high-fat breakfast when taking Adderall XR vs not eating breakfast at all.  Eating breakfast reduced the effectiveness.

“The study had a single-dose, open-label, randomized, four-treatment, crossover design in which healthy subjects received …  20 mg Adderall XR™ in the morning after an overnight fast or a high-fat breakfast …   Amphetamine concentrations were markedly lower when the subjects had eaten breakfast”4.
Other sources also back up this finding:
STARVATION and amphetamine both increase behavioural arousal, and have been postulated to act through adrenergic mechanisms in the brain stem. Amphetamine is believed to induce psychomotor excitation by releasing brain catecholamines, blocking their re-uptake from the synapse and mildly inhibiting the action of the catabolizing enzyme, monoamine oxidase. The drug also accelerates the turnover of nor-adrenaline in the brain stem reticular formation. Food deprivation increases electrophysiological arousal in the mesencephalic reticular formation and other areas and Dell postulated that behavioural arousal induced by starvation resulted from the release of catecholamines from the adrenal medulla and their consequent action on brain stem excitatory areas.(5)
Locomotor activity induced by d-amphetamine was found to be potentiated by food deprivation … (6)

REFERENCES

  1. Adderall XR (amphetamine) US prescribing information. Shire US Inc. June .Adderall XR (amphetamine) US prescribing information. Shire US Inc. June 6, 2006.
  2. Adderall (amphetmine) US prescribing information. Shire US Inc. November, .Adderall (amphetmine) US prescribing information. Shire US Inc. November, 2010.
  3. Adderall XR (amphetamine) Canadian prescribing information. Shire Canada .Adderall XR (amphetamine) Canadian prescribing information. Shire Canada Inc. September 30, 2009.
  4. Effect of Food on Early Drug Exposure from Extended-Release Stimulants: Results from the Concerta®, Adderall XR™ Food Evaluation (CAFÉ) StudyJ. F. Auiler, K. Liu, J. M. Lynch and C. K. Gelotte. 2002
  5. Campbell BA, Fibiger HC. Potentiation of amphetamine-induced arousal by starvation. Nature. 1971 Oct 8;233(5319):424-5. PubMed PMID: 4940440.
  6. An inhibitory role for brain serotonin-containing systems in the locomotor effects of d-amphetamine.J Pharmacol Exp Ther July 1976 198:12-22; published online July 1, 1976, PMC2913905
  7. http://www.whatarenootropics.com/adderall-use-guide/

Pass a Drug Test With Adderall

This article isn’t about using crackpot home remedies to flush adderall out of your system.  This article references real studies with documented results to help you make the best decision for yourself.  To pass a drug test with Adderall there are a few methods one can take.  The real question is …

How much time do you have before the drug test?

Detection usually occurs between one to three days after amphetamine (Adderall) is taken.  Amphetamine is significantly excreted in the urine.  The amount excreted is heavily dependent on your urinary pH.  There are various methods to pass a drug test with Adderall.   One popular method includes trying to quickly get all of the amphetamine out of your system before the test (lower your urinary pH) or to reduce the amount excreted in the urine by greatly increase your urinary pH (by ingesting sodium bicarbonate aka Alka-Seltzer or Baking Soda).

Pass a Drug Test With Adderall

The amount of Adderall you consumed will be a factor in terms of passing a test.  There was a study done in 1998 that tested seven healthy male volunteers by giving them an oral does of 5mg, 10mg, or 20mg.  Then their urine was collected at 2, 4, 8, 12, 18, and 24 hours post dose.

Source: Journal of Analytical Toxicology, Vol. 22, October 1998. Page 484

Increase Excretion of Adderall (Amphetamine) via acidification of your urine

Take ammonium chloride 500 mg orally every 4 hours.  This is the approved practice for treating amphetamine toxicity (when people overdose on Adderall or Meth).

Source: Manual of Emergency Medicine By G. Richard Braen. Page 675

Where’s the proof?

Urinary acidifying agents (ammonium chloride, sodium acid phosphate, etc.) increase concentration of the ionized species of the amphetamine molecule, thereby increasing urinary excretion.

source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/011522s032,033lbl.pdf

Less than three days

You’re only hope is to either get it all out or decrease the amount excreted in the urine

adderall-drug-test1

adderall-drug-test2.png

adderall-drug-test4

More than three days

You are probably in the clear

Excretion Time Table

adderall-drug-test-5