Monthly Archives: March 2014

Adderall Last Longer

How can you make your adderall last longer?  Quick tips to make your Adderall last longer.  This post will explore how to make the effects of adderall last longer.

adderall-last-longer

FAQ

Does Alka-Seltzer make Adderall Last Longer?

Yes

Alkalinizing Agents: Adderall absorbs better in less acidic gastrointestinal conditions. You can decrease the acidity of your GI tract by taking one or two tums or half a teaspoon of baking soda (mixed with water) about an hour before consuming the amphetamine. Be careful not to take too much baking soda, as its chemical reaction with stomach acid can cause nausea and vomiting 1-2,7.

Will Antacids and Proton Pump Inhibitors make my Adderall last longer?

Antacids1-2 and proton pump inhibitors3 increase the absorption of amphetamines, but not the duration!

Will food effect my Adderall ?

Yes, try not to eat before taking your adderall or immediately afterward.

A study compared the effect of a high-fat breakfast when taking Adderall XR vs not eating breakfast at all.  Eating breakfast reduced the effectiveness.

“The study had a single-dose, open-label, randomized, four-treatment, crossover design in which healthy subjects received …  20 mg Adderall XR™ in the morning after an overnight fast or a high-fat breakfast …   Amphetamine concentrations were markedly lower when the subjects had eaten breakfast”4.
Other sources also back up this finding:
STARVATION and amphetamine both increase behavioural arousal, and have been postulated to act through adrenergic mechanisms in the brain stem. Amphetamine is believed to induce psychomotor excitation by releasing brain catecholamines, blocking their re-uptake from the synapse and mildly inhibiting the action of the catabolizing enzyme, monoamine oxidase. The drug also accelerates the turnover of nor-adrenaline in the brain stem reticular formation. Food deprivation increases electrophysiological arousal in the mesencephalic reticular formation and other areas and Dell postulated that behavioural arousal induced by starvation resulted from the release of catecholamines from the adrenal medulla and their consequent action on brain stem excitatory areas.(5)
Locomotor activity induced by d-amphetamine was found to be potentiated by food deprivation … (6)

REFERENCES

  1. Adderall XR (amphetamine) US prescribing information. Shire US Inc. June .Adderall XR (amphetamine) US prescribing information. Shire US Inc. June 6, 2006.
  2. Adderall (amphetmine) US prescribing information. Shire US Inc. November, .Adderall (amphetmine) US prescribing information. Shire US Inc. November, 2010.
  3. Adderall XR (amphetamine) Canadian prescribing information. Shire Canada .Adderall XR (amphetamine) Canadian prescribing information. Shire Canada Inc. September 30, 2009.
  4. Effect of Food on Early Drug Exposure from Extended-Release Stimulants: Results from the Concerta®, Adderall XR™ Food Evaluation (CAFÉ) StudyJ. F. Auiler, K. Liu, J. M. Lynch and C. K. Gelotte. 2002
  5. Campbell BA, Fibiger HC. Potentiation of amphetamine-induced arousal by starvation. Nature. 1971 Oct 8;233(5319):424-5. PubMed PMID: 4940440.
  6. An inhibitory role for brain serotonin-containing systems in the locomotor effects of d-amphetamine.J Pharmacol Exp Ther July 1976 198:12-22; published online July 1, 1976, PMC2913905
  7. http://www.whatarenootropics.com/adderall-use-guide/